In 2020, a new genotype of H5N1 originated, belonging to clade 2.3.4.4b. This came from a genomic reassortment where two viruses infecting one host swap sequences, in this case 2.3.4.4b H5N8 and low-pathogenicity avian influenza. This led to more H5N1/LPAI reassortment events, and today's H5N1 is panzootic, spreading in fur farms, marine mammals, dairy cattle and wild birds.
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