@mangeurdenuage one (noticable) sexually transmitted bacterial/fungal (yeast) infection symptom is the sensation of extreme discomfort, similar to burning/boiling liquid on the skin, especially when pissing. The meme's assumption is, that the female had some STI with 0 symptoms to her (commonly, many common STDs present 0 or all unnoticable symptoms), then the male acquiring said STI, and then the male has painful symptoms afterwards. A bacterial infection, for example, should take about 3-ish days to come out.

If you are interested in science, then Rub some ICE HOT THERMO GEL on cock or pussy to experience this pain without the disease! (DONT DO THAT IT IS INCREDIBLY NOT GOOD)