@Gran3Walder @LukeAlmighty you really have to know the vibe of the table and the moment.
my character got raped in the last campaign i played and it was fucking hilarious. the whole night, it was a massive celebration so he was doing hella drugs and drinking like crazy, he was winning all these competitions and stuff, basically on cloud 9. some dwarf lady complimented him and he was on his high horse and drugged out of his mind so he took another drink from her and it was spiked. fast forward to the rest of the party finding her straddling my character. one of the best sessions i've ever played, shit was so fucking funny.
then there are succubi, whose entire existence requires either raping or seducing people. idk if it was toned down to be just a kiss for 5e or if it's always been that way in d&d, but magically charming someone so you can kiss them to death still probably constitutes as rape. a part of the campaign i run has a succubus as an enemy that tries to lure the person with the weakest wisdom and yeah, pretty much rape em. i would say i wouldn't do that at a table full of people who wouldn't be cool with that, but i probably wouldn't be playing with them in the first place.
murder hobo is pretty much the same thing as rape hobo when it comes to player actions, though. if they do it completely out of the blue, especially to another player, kick em out. if things just ended up progressing in a weird way, for instance if they wanted a girl at a bar to go to bed with them and they used a charm to do it, then punish them a bit. maybe it turns out that girl was a succubus and she was the one trying to get with them instead, and it leads to them almost dying or nearly dying. they'll think twice about doing it in the future. or maybe, if the character remembers the charm, she'll inform the guards and there will be a confrontation in-game about it. that's all part of the fantasy game that you're playing too, and some players don't understand that they can't just skyrim their way through everything until they face repercussions.
it's not really related to rape necessarily, but the charming thing. that same character of mine, he's a bard and had a way of charming people when he played. so every time i played at a tavern i'd charm people and they actually weren't aware of the charm whether it succeeded or failed, so i figured there was no harm in it. well, turns out charming the wrong people can also bring about issues, like middle-aged, aristocrat, gay men finding you so attractive they stalk you everywhere.
long story short just make sure everyone is having fun.