Mad speculative hypothesis: 3D printing technology can't be considered mature until it is possible to print, in situ, a fully fuelled fission reactor (complete with shielding, heat exchangers, turbines, etc) that—when you fill it with a moderator working fluid—starts to work as soon as you install the neutron initiator source.
(Stop and think about the individual challenges FOR 3D PRINTING we need to overcome before actually doing this. It's a thought experiment, not a challenge.)