Erik Uden 🍑10:50 (Continuation of the E-Mail)
Ever since compound day 5, however (today is compound day 11), I have had lessened to no symptoms. The symptoms were around 10-30% as strong as during my one state on day 5, and instead of them lasting longer, the high phases are only 2-3 hours. The fact these effects lessen may have been due to me now drinking more, but also because I could psychologically deal with and prepare for the symptoms. On day 5, I didn't know what was going on, now I don't stress out if I may feel disoriented for a short time. In the morning, especially before, or a few hours after, the dosing at 09:40, I feel as if there has been no effect at all. Around the afternoon (12:30 - 15:30), I may experience the height of the compound, but have since always managed to still do work or complex tasks during this phase.The only thing that I notice with taking the compound today, is mostly when I concentrate on a task so much that when I look away, I become disoriented for a second, and also my mind wanders off and loses track more easily. However, I also realized that every day since day 5, the severity of these effects became less and less, meaning I might become accustomed to this state, or am able to learn how to deal with it better. I don't feel like the side effects lessen (below 5-20%), but I can find ways to handle them better. Right now is a good example of that. It's been two hours since taking the compound, slight effects settle in, I notice them if I concentrate on them, but if I simply acknowledge that something about my state of mind has changed, I can still continue to focus on writing this E-Mail.
Overall, the only side effects of this drug were sometimes weed-like symptoms, but no pain, no severe problems, no sleep deprivation, and it doesn't even taste bad. I've had a very good experience both with the compound and at ICON for the past weeks.
Yours sincerely,
Erik Uden
Participant with the compound RO7268489
(sent 11:51)
13:31 (written afterwards)
Some random Belgian number called me and hung up the moment I picked off.
15:00 (written afterwards)
I went outside and walked for an hour! It was very refreshing.
18:25 (written afterwards)
The head physician came to me and talked about how the meeting went with the sponsor. I was still in a half-sleep, as I tried to recuperate some sleep I didn't get last night due to staying up so late to finish some work. He told me that the Sponsor (Roche) has decided to no longer give me the compound RO7268489, as they are worried about my wellbeing. I had no say in the matter, as you could see, my E-Mail was even quite optimistic about my future experience with this drug. However, they saw too many risks in it, and would like for me to stop. Especially because they were worried about possible withdrawal symptoms. Hence, the new plan is to have me stay at ICON until the 21st, do all the blood and CSF samples as the schedule says, but never take any of that medicine again. My study has just been converted to a “withdrawal study”. I think that will be very interesting.
This blog is obviously not over, I'll document everything until the last ambulatory visit in late November! However, it may be that the fun part has just ended, or perhaps started... We will see!
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