Erik Uden 🍑Day 014 of the Multiple Sclerosis Study
(Compound Day 11) Monday on 2024-09-16
Groningen, Netherlands (GMT+1)
- BP = blood pressure
- HR = heart rate
- SB = (study bound) meal controlled for the study
07:30 Wellbeing (Pre dose)
08:40 ECG (3x)
08:40 Vital signs (BP, HR)
08:55 Blood sampling
- FK: Sample 32
- SR PD 2-AG: Sample 316
08:55 Transfer bloodtubes
09:10 Breakfast
09:40 Dose (RO7268489 or placebo)
09:40 Dose check
09.40 Water fast (Start)
11:40 Water fast (Stop)
11:40 Moming snack
13:10 Lunch
15:30 Afternoon snack
18:30 Dinner
19:00 Wellbeing
21:30 Evening snack
Water intake: 6 glasses (three tea, one compound)
My Notes for Today10:50 (written afterwards)
A number from the Netherlands began calling me, I panicked for a second, then accepted the phone call. It was the head physician asking me to write yet another E-Mail with my experiences of the past days, because he'd wish to present them to the Sponsor (Roche) with whom he had a meeting about an hour after the call. However, right after hanging up that conversation, he calls again, I accept the call and turns out he didn't consciously try to call me again, as I was just hearing background noise, most likely because his telephone was in his pocket.
Regardless, I've written the following in that E-Mail:
Dear▯▯▯▯▯ ▯▯▯▯,you asked me to describe my experience with the compound in the past couple of days, I will do so in the following E-Mail:
The first time I took the compound, I had mild (10%) symptoms that were similar to Marijuana for about three hours. As I didn't have much to concentrate on, I also let loose, just relaxed, accepted and expected side effects. However, I always felt like I was in control and could behave normally if I concentrate on doing so!
The following days (compound days 2-4), I felt nothing. No side effect, no difference in attention span, or cognitive side effects (I had work meetings, wrote long E-Mails, call people and organize things, just like without the compound).
On day 5 I had a panic attack when the effects suddenly set in, not even an hour earlier I had a work meeting that went flawlessly. As described previously, I was having the exact same panic attack as when I first took weed (edibles, ate a bit too much) over a year ago. Hence, I am prone to such panic attacks caused by the sudden feeling of disorientation or loss of control, however, with the knowledge of what I can expect as a side effect to happen, both with the weed over a year ago and the compound in this study, I never had a panic attack again. I am sure that if I had been a little more attentive or was more aware of the fact that the effects might settle in later, it could've been easily prevented. Since the effects lessened from day 1 to the morning of day 5, I thought I'd never experience any symptoms anymore, if I hadn't been in that mindset and more educated about this medicine, I am sure the panic attack would not have happened.
To be continued...
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