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Day 008 of the Multiple Sklerosis Study
(Compound Day 5) Sunday on 2024-09-10
Groningen, Netherlands (GMT+1)

07:30 Wellbeing (Pre dose)
08:40 ECG (3x measurements after 10m)
08:40 Vital signs (BP, HR)
08:55 Blood sampling (PK: Sample 15)
08:55 Transfer bloodtubes
09:10 Breakfast (Start)
09:40 Dose (RO7268489 or placebo)
09:40 Dose check
09:40 Water fast (Start)
11:40 Water fast (Stop (
11:40 Morning snack
13:10 Lunch
15:30 Afternoon snack
18:30 Dinner
19:00 Wellbeing
21:00 Evening Snack

Water intake: 1 (glass)

• 07:15 - Now slight pain in the lower left back. It extends to the soreness of my legs.
• 07:15 - Now arms are sore and slight muscle ache too
• (already since yesterday until now) a slight pain in my lower left back, under the lumbar puncture. It extends until my upper left leg. Might be soreness/stiffness/pain, might be something else. Headaches are gone!

08:31
Just managed to have a shower before any ECGs! I was just on time!