Embed Notice

Day 005 of the Multiple Sklerosis Study
(Compound Day 2) Saturday on 2024-09-07
Groningen, Netherlands (GMT+1)

• BP = blood pressure
• HR = heart rate
• SB = (study bound) meal controlled for the study

06:30 Intravenous catheter (Check)
07:15 Telemetry (Continue)
07:15Urine collection (Continue)
07:30 Wellbeing (Pre dose)
08:30 Telemetry (Start subject lay down [24h])
08:40 Telemetry (Make ECG print [3x])
08:45 Telemetry (Stop subject lay down [24h])
08:45 Vital signs (BP, HR)
08:55 Blood sampling

• PK: Sample 12
• PL PD 2-AG: Sample 105
• SR PD 2-AG: Sample 307
• Remove Intravenous catheter

8:55 Transfer bloodtubes
9:00 Urine collection

• Stop container 3
• Stop collection

09:00 Transfer Urine containers
09:10 Breakfast (Start)
09:40 Dose (RO7268489 or placebo)
09:40 Dose check
09:40 Water fast (Start)
09:40 Telemetry

• Stop
• Disconnect + Archive

10:40 Intravenous catheter (Inspection)
11:40 Water fast (Stop)
11:40 Morning snack
13:10 Lunch
15:30 Afternoon snack
18:30 Dinner
19:00 Wellbeing
21:30 Evening snack

Water intake: 7 (glasses, one tea, one compound)
Headache 19:00

07:02
I woke up through my second alarm (one at 06:50, the other at 07:00), and then dropped my phone. I have to sincerely apologize to my entire study group.

Also look at my schedule!! Look at how small it is for today!

08:55
I did my blood samples and they went fine, but after removing the cotton wool they put on for sleeping, parts of it got stuck or were left around the cannula (some of it got stuck inside the tube that goes to the left from my perspective), the assistant said it was fine. Whilst trying to clean a clot, they also put in saline solution (salt solution) halfway, and then drew blood into the same syringe by pulling it back out. It was all probably still sanitary, just very unconventional compared to the other days.

09:07
I just got done with some other sampling, when I realized they forgot to take out my cannula. I told a doctor that we may need to do it after my breakfast, he said “we can do it quick”, so he actually did take my intravenous catheter out.... with 45 seconds left to go to the breakfast. Sadly it bled through the paper they taped over it a bit, but when I arrived at breakfast I was “on time” (after eating one piece of bread so that I technically began eating).

09:10
Look at my breakfast (picture 1), breakfast is always an SB (study-bound) breakfast, meaning the food I have to eat is very much controlled. I am allowed to choose two savory and two sweet toppings.

09:34 (written afterwards)
I googled the compound name and figured out our sponsor was Roche! They intend on publishing this in some “high-impact journal” like Nature! Hehe, I can always claim I helped publish a study in Nature. “Yeah, I was there, I was the lab rat”.

There was much less anticipation in giving the drug today. Just two assistants giving me the medicine. We read through what it said on the compound flask. I've been trying to get a picture of it when they're not looking, but they're guarding it like gold (for obvious reasons). Apparently this compound is made at ICON only 48 hours in advance and specifically has my name on it. Very interesting to see what can be done if good money can be made from it.

09:42
Just took the compound for a second time! Let's see what effects I'll have today. I also have very little to no appointments today, so a lot of rest and having fun.

09:56
A doctor is talking to me and claims to speak like... dozens of languages? Who is this guy? “it's just an Afghani language...” what does that mean? “My friend is from this region of Syria where they speak [...], so I learned that too” WHO ARE YOU?

10:14
Oh man, I'm so happy there are no cables or catheters running through or around my body anymore!