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Day 002 of the Multiple Sklerosis Study
(Compound Day -2) Wednesday on 2024-09-04
Groningen, Netherlands (GMT+1)

Comment: Pre dose CSF sampling

• BP = blood pressure
• HR = heart rate
• SB = a meal that is observed for the study

07:15 ECG (3x mesasurements after 10 minutes in supine position)

07:15 Vital signs (BP, HR, T [3x measurements])
07:15 Intravenous catheter (Insert)
07:30 Wellbeing
08:05 Blood sampling

• PL PD 2-AG: Sample 101
• Expl BM: Sample 201
• SR PD 2-AG: Sample 301

08:05 Transfer bloodtubes

• PD CSF: Sample 501 Collection 1

08:10 CSF sampling

• PD CSF: Sample 101
• Collection 1

08:10 Transfer CSF tubes
08:10 Supervision (Start category 2 for CSF sampling)

09:10 Supervision

• Stop category 2 for CSD sampling (1 hour after the CSF sampling of the last subject)

09:25 Breakfast
13:00 Lunch
14:00 Discharge

• Only reserve volunteers
• Time may differ

15:00 Intravenous catheter

• Check

15:30 Afternoon snack
16:10 Cogstate (Neurocognitive Test Battery training)
19:00 Wellbeing
19:30 Dinner
21:30 Evening snack
22:00 Intravenous catheter (Check)

Water intake: 7 (glasses, two of which were tea)
Headache from 14:30 to 16:30
Increasing back pain 13:20 to 17:35

06:30
Was woken up by assistants and doctors wanting to put ECG stickers on me. Afterwards I was left alone, and thought I had a bit of time left, so I didn't go to the bathroom right away.

07:05
I thought I still had 10 minutes left, as my first appointment for the ECG was in 10 minutes, however, for a good ECG you need to begin resting 10 minutes prior. So I was told to lie down and wait.

07:15
This was my first appointment of the day, the ECG went well. I was lying still for 5 minutes and then a blood pressure check, as well as a different test would be performed.

07:30
Around this time the ECG testing must've been over, so I went to the bathroom and came back. Today was not a day where urine would be sampled, so I could go to the bathroom normally. The bathrooms would be locked on such days, so you had to get a key from the “urine station”. Although annoying, I know sure as hell that I'd forget without such measures.

After coming back we deviated from the schedule a bit. I guess me questioning so many things the day prior made them worry I'd leave the study if I don't get answers. I was walked into an office with the head physician and also “mastermind” of this study. I was generally interested in how the medicine worked, as the study paper us participants got only talked about side effects, the procedure, and legal stuff. The doctor was very interested in explaining every minute detail, although he had to often repeat things in layman's terms for me.

The way I understood it is that the compound we are testing builds an extra coating on the cannabinoid receptors of the central nervous system. They also have something to do with Cannabis, although I have zero idea what they do in regular day to day life. This coating gets destroyed for multiple sklerosis patients, which this drug it could be rebuild. For us, it could potentially build another coating, making the receptors far more sensitive to cannabis. He told me if we were to take cannabis during this study, we would feel the effects 100 times. This explains why many of the side effects on higher doses are similar to that of weed (panic attacks, etc.) It also explains why we had a specific questionnaire regarding weed and how badly we want it. He also told me that weed would have the exact same effect as usually after the 15th of November, the day the study is completely over.

[To Be Continued...]