Potential thoughts:
Riverboat - a race, players have to prevent sabotage, the pilot/captain of the boat is a vampire, there's a Promethean chained in the furnace providing power
Town - a cursed mine, a saloon run by a succubus/incubus, a wraith that's challenging anyone she meets to a duel until her murder is solved, a wendigo in the woods, a buffalo hunter brings in a strangely coloured hide