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depression and autism are often co-morbid.
firstly difficulties in life created by autism (problems making friends, having relationships, struggled at work, with stress and family) can directly cause depression.
secondarily the brain chemistry of people with autism is different, also contributing.
thirdly autistic people often have difficulties with self-monitoring, not realizing what causes their depression.
fourthly and lastly learned evasion strategies to avoid uncomfortable situations prevent patients who realize their issues to take positive action.