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- Embed this notice@Thusnelda @Xenophon @Dan_Hulson @graf melatonin dosage isn't relevant imo. it's a hormone, and the body's secretions are like 100x the amount found in supplements. the only thing it affects is the sophoric effect that makes you sleepy in the first 30m but you get used to it in my experience. there's no upper limit for toxicity either. I would just do 1-5mg (or less) at 5 hours before your desired bed time and just track how it affects you. I have a timer on my wrist watch at 7pm every day