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- Embed this notice@Thusnelda @Xenophon @Dan_Hulson @graf melatonin works. it acts on two recepters, type I recepters causes the sophoric/hypnotic effect that makes people tired within the 30m timeframe that they they take it. this is not useful imo. it also effects type II receptors which affect the circadian rhythm. if you take melatonin (0.3mg-1mg+) at just before the correct time (30 minutes before dim light melatonin onset) you can trick your body into early production of melatonin secretion (100-1000x more concentrated than any supplement). the tricky part is figuring out your DLMO, the easiest way being to take rectal thermometer measurements every hour until you find your core body temp to decrease lol