After a brief bit of confusion swapping TX and RX on the header to the FTDI (because come on, who doesn't do that the first time you bring up a board) the supervisor is talking to me on the UART.
Now to try and turn on the 12V rail, energizing the inputs to all of the DC-DCs across the board. This is the first point in the bringup where there's a nontrivial risk of magic smoke (since the 3V3_SB rail is on a super low current LDO).