After 467 quests and 144 activities, over 200 hours, I’ve only had one quest bug and one crash to desktop. They did a really good QA job.
The bugged quest is in Neon city, where I have to meet a gang member in a bar but the door upstairs is locked. It’s because I left the bar while an NPC was unlocking the door.. and they didn’t factor in a player doing that. Oops.