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Fire inside an enclosed space station is very bad, so NASA has been experimenting for the last 8 years to understand how fires could start and grow in a weightless environment. The program was called Saffire, and the final experiment, Saffire-VI, has just wrapped up. As uncrewed Cygnus cargo spacecraft departed from the ISS, researchers ignited a fire using materials like plexiglass and cotton. Then, they tracked how the fire spread, releasing toxic chemicals and smoke.

https://www.nasa.gov/centers-and-facilities/glenn/flame-burns-out-on-nasas-long-running-spacecraft-fire-experiment/