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It would be convenient to address the voxel data as a stack of horizontal slices, because that's how it's exported from lots of existing tools. I have to rotate it 90 degrees though, because scanning out is faster if each column's data can be addressed as consecutive bytes.
It's a small change, but there's a 6.5x difference in speed between the two orientations, which directly translates into voxel density in the final output.