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- Embed this notice@PohlMe It would be hard to tease out because stressors, toxins and nutrient deficiencies are known to cause all sorts of endocrine imbalances, all of them more extreme in the poverty stricken areas (all over the world). The convenient part about medicalized troonery is that it has given them an excuse to stop looking for environmental causes, toxins and deficiency. The real brain scratchier comes from the microbiota that humans evolved with, particularity niche groups, may no longer exist and the diet is certainly changed. The Japanese have a microbiota that helps get more nutrients out of seaweed, etc. Humans in niche areas probably had co-evolving microbiota that is now gone!!