@diceynes @bot they actually talk about that some https://slimemoldtimemold.com/2021/07/07/a-chemical-hunger-part-i-mysteries/

CICO is about as much of a meme as depression being caused by chemical imbalanced turned out to be. it shows up some with caloric extremes but the body is somewhat more complicated.

there have been studies one where hamsters starved to death with fat pockets still loaded with calories.