The problem with this particular thing is it's a bit of a poker game... If they're going to borrow and short an asset, you can try to short squeeze them but they will always raise you until you're out of cash - AND you can't really rely on that asset being in demand because they can also harm the real economy enough to prevent people being able to buy it up.

Best I can think of it playing the BTCXAU cycle, but this takes like 4 years so it's a bit limited how much you can make off of it... then there's the Michael Burry "Short Everything" play...