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What does the quote in my first post (about if we could see a significant change in the mutation landscape) mean?

This implies the natural evolution isn't likely to alter current trends, given Omicron's dominance. However, some rare situations might occur, such as zoonotic spillover (from animals) or agentic shift (different strains combining in an individual.) Low vaccination rates might also change evolutionary pressure, but we may have enough immunity to prevent that.

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