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jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:13 JST jonny (good kind)

I never heard of these whole ass deeply evolutionarily preserved organelles in my cell bio class. Anyone know what these dang things are?
https://en.m.wikipedia.org/wiki/Vault_(organelle)
In conversation about 7 months ago from neuromatch.social permalink
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  Vault (organelle)
  
  The vault or vault cytoplasmic ribonucleoprotein is a eukaryotic organelle whose function is not yet fully understood. Discovered and isolated by Nancy Kedersha and Leonard Rome in 1986, vaults are cytoplasmic organelles which, when negative-stained and viewed under an electron microscope, resemble the arches of a cathedral's vaulted ceiling, with 39-fold (or D39d) symmetry. They are present in many types of eukaryotic cells and appear to be highly conserved among eukaryotes. Morphology Vaults are large ribonucleoprotein particles. About 3 times the size of a ribosome and weighing approximately 13 MDa, they are found in most eukaryotic cells and all higher eukaryotes. They measure 34 nm by 60 nm from a negative stain, 26 nm by 49 nm from cryo-electron microscopy, and 35 nm by 59 nm from STEM. The vaults consist primarily of proteins, making it difficult to stain with conventional techniques. Structure The protein structure consists of an outer shell composed of 78 copies of the ~100 kDa major vault protein (MVP). Inside are two associated vault proteins, TEP1 and VPARP...
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:07 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle this is incredible, an entirely different means of creating cellular structures by CHAINING TOGETHER MULTIPLE RIBOSOMES INTO A POLYRIBOSOME AND PRINTING A 3 DIMENSIONAL STRUCTURE AND THIS VIDEO HAS 325 VIEWS
  https://www.youtube.com/watch?v=dKvOtb6nkAo
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  1. Polyribosomes Are Molecular 3D Nanoprinters That Orchestrate The Assembly of Vault Particles
    
    from DGIT CTRL
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:08 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle especially when we know so little about the immune system i would be wanting to know more about these extremely well preserved evolutionary organelles that are very costly to produce but are still extremely common among cells!!!!>?!?!!??!?!
  
  In conversation about 7 months ago permalink
  
  Rich Felker repeated this.
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:09 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle yuck. cell.
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  1. Confident the lab had something unprecedented, Rome mailed the work to one of the top basic research journals, Cell. Its famously opinionated editor, Benjamin Lewin, rejected the submission without sending the manuscript out for review. The journal would be happy to reconsider, he added, once the lab identified a function for vaults. Crushed, the team pivoted to a more specialized cell biology journal, and the paper was quickly published.
    https://media.neuromatch.social/media_attachments/files/113/656/303/744/887/801/original/f9eed5cec5020f15.png
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:09 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle cells don't just make 'the most massive particles made by human cells and among the most abundant' for no reason
  
  In conversation about 7 months ago permalink
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:10 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle FIGURE OUT what is IS DOING before you PATENT KNOWING ABOUT IT
  
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:11 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle holy shit it seems like we should maybe figure out what these do!?!??!!??!?!?!
  
  In conversation about 7 months ago permalink
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  jonny (good kind) (jonny@neuromatch.social)'s status on Sunday, 15-Dec-2024 20:03:11 JST jonny (good kind)
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  - Stephen Royle
  @steveroyle i fucking do not like UCLA's research culture at all and i wish i knew it was like this before i came here
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  1. The ones in the microscope on this day were produced in genetically modified yeast and loaded with an immune signaling molecule called CCL21 that has shown tumor-fighting potential. Vault Pharma, a company co-founded by Rome that works out of an incubator space at UCLA, hopes to start a clinical trial in late-stage cancer patients as soon as this year. It would mark the first time synthetic vaults have been injected into humans, and perhaps the beginning of a new turn in the spotlight for these mysterious organelles.
    https://media.neuromatch.social/media_attachments/files/113/656/293/436/207/912/original/ffbe52f3efa19650.png
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  Stephen Royle (steveroyle@biologists.social)'s status on Sunday, 15-Dec-2024 20:03:13 JST Stephen Royle
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  @jonny there’s a great article in Science about the guy that’s spent his career trying to answer that very question https://www.science.org/content/article/biologist-aims-solve-cell-s-biggest-mystery-could-it-help-cancer-patients-too
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  GeePawHill (geepawhill@mastodon.social)'s status on Friday, 27-Dec-2024 12:35:53 JST GeePawHill
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  - Lio Hong
  @liohong @jonny Okay, but, for the record, it's actually kinda glorious how little we understand.
  Like, in my case, the passive "hard-wired" immune system is complicated as hell. But the active "game-time" immune system is just flat fucking insane.
  Or, the organic explanation for what I am quite confident was organic "major depressive disorder" that I underwent for 30 years. (Now in remission for almost a decade, and we do not have any idea why.)
  On my good days, it's a world of wonder.
  
  In conversation about 6 months ago permalink
  
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  Lio Hong (liohong@mastodon.social)'s status on Friday, 27-Dec-2024 12:35:54 JST Lio Hong
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  @jonny My former supervisor mentioned these to me last year as well, and while my interests lay elsewhere, the sheer mystery of vaults did leave me pondering the limitations of the modern scientific pursuit
  
  In conversation about 6 months ago permalink
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  jonny (good kind) (jonny@neuromatch.social)'s status on Friday, 27-Dec-2024 12:35:56 JST jonny (good kind)
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  - Lio Hong
  @GeePawHill @liohong i also love the mystery of biology, it's the whole reason i hang with biologists. i do think we should probably figure out what an organelle that many cells across evolutionary time spend a shitload of resources to produce does at least on a basic level
  
  In conversation about 6 months ago permalink
  
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