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Victoria Stuart 🇨🇦 🏳️‍⚧️ (persagen@mastodon.social)'s status on Tuesday, 19-Nov-2024 12:11:03 JST Victoria Stuart 🇨🇦 🏳️‍⚧️

Stem cells: Scientists recreate mouse from gene older than animal life
https://www.sciencedaily.com/releases/2024/11/241118125716.htm
* unicellular Sox & POU transcription factors
* creation of mouse stem cells capable of generating fully dev. mouse
* reshapes understanding of genetic/evolutionary origins of stem cells
* poss. critical for advent of stem cells & animal multicellularity
Emergence of Sox & POU transcription factors predates origins of animal stem cells
https://www.nature.com/articles/s41467-024-54152-x
#StemCells #evolution #MolecularBiology
In conversation about 11 days ago from mastodon.social permalink
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  The emergence of Sox and POU transcription factors predates the origins of animal stem cells - Nature Communications
  
  from Jauch, Ralf
  
  The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals and show that unicellular SOX can replace SOX2 to induce pluripotency, whilst unicellular POU differs from OCT4.

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