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#COVID19 Therapeutics for Nonhospitalized Older Adults

📌 Three therapies are recommended among eligible adult outpatients: nirmatrelvir/ritonavir, remdesivir, and molnupiravir

📌 Because remdesivir requires parenteral administration, the oral antivirals, nirmatrelvir/ritonavir and molnupiravir, are more feasible for widespread use. However, because ritonavir inhibits the cytochrome P450 3A4 (CYP3A) enzyme, it can interfere with the metabolism of many medications

https://jamanetwork.com/journals/jama/fullarticle/2824607?guestAccessKey=1e2a25fa-2247-485b-9f10-f3fa630b4c6d&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=100724&adv=000001935867