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Erin Kissane (kissane@mas.to)'s status on Tuesday, 24-Sep-2024 03:53:35 JST Erin Kissane
in reply to

Mostly I want to say: There's a ton of evidence that covid damages cognition to some degree, even in clinically mild cases. But the specific relationship between subjective experience and objective measures is genuinely complex, so it's good not to over-reduce it.
(Metacognition is wickedly tricky, as anyone with a history of "brain fog" and/or loved ones with cognitive decline can attest. Some conditions are subjectively detectable and some not and severity CAN play a role but doesn't always.)

In conversation about 2 months ago from mas.to permalink
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  Erin Kissane (kissane@mas.to)'s status on Tuesday, 24-Sep-2024 03:53:36 JST Erin Kissane
  
  I am very anti getting covid *and also* this Lancet paper actually does a nice job of noting that the small cognitive deficits that persisted after clinically mild pre-vax-world covid may be too subtle to be noticed by the subjects, but there are other confounding factors & mysteries.
  IRL many folks are *very* aware of cognitive problems after infection, so this isn't necessarily a case of special sneaky damage that's always subjectively invisible at high severity.
  https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00421-8/fulltext
  In conversation about 2 months ago permalink
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  1. Notably, none of the volunteers reported subjective cognitive deficits. This apparent discrepancy between objective and subjective measures could be interpreted as indicating that the tasks are sensitive enough to detect small changes in cognition that are too subtle for the volunteer to be metacognitively aware of. It is important to note though that this interpretation is limited by the lack of specific questions about lasting changes in cognition–instead, volunteers underwent a structured interview about their overall health. Within the broader literature, larger observational studies have reported mixed results. Subjective symptoms have been reported 36 months post infection,28 which accords with the observation of objectively measured deficits in task performance a year or more post infection with Wildtype virus in our epidemiological research,11 and with the objective measures observed up to the 12 month final timepoint in the present study. However, correlations between objective measures of cognition and subjective assessment of cognition after COVID-19 are modest,29 and hard to confirm, particularly in less severe cases.30 Given that no direct assessment of subjective cognitive symptoms was performed and the sample size was small, the complex interaction between objective cognitive ability and subjective cognition cannot be elucidated in the current study. Relatedly, the clinical relevance of the observed cognitive changes remains unclear.
    https://media.mas.to/media_attachments/files/113/188/294/020/027/058/original/d6ae157802cfadf4.png
  GreenSkyOverMe (Monika) repeated this.

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