@b0rk something *very* specific to a use case I used to have: too many files in a lustre folder (fewer than 1e6 tho!) which meant that, among other things, `ls -l` was vastly slower than `ls -1` because it would bottleneck on metadata server queries.
This was a problem for importing python, because it walked lots of folders (esp with .egg files) on every import -- basically a DDOS against the metadata servers.
(I may be misremembering the specifics, but I think this is broadly accurate.)