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https://gizmodo.com/youre-practically-guaranteed-to-get-alzheimers-if-you-h-1851461024

A guarantee you'll get dementia if you have this gene.

Honestly, if this doesn't make the case for human genetic engineering, then I don't know what will. There is nothing sacred about the human genome, and we ought to be able to hack it as we see fit for our best health.