Ordering replies in chronological order is not a good general solution, it amplifies reply-guys, and doesn't give good context for the reader.
Ideally, it should be configurable for each user, but here is a general idea, order of replies:
1. Replies from people I follow
2. Replies from people who follow me
3. Other replies without questions
4. Other replies with questions
This could be used as a basis for filtering as well, if you don't feel like answering, then hide all questions.