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   Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:02:40 JST Marc Veldhoen

   Long-term vaccination effects.

   It is strange to see the messages about not knowing the long-term effects of the COVID-19 vaccines. We do, and yes, of course, there are long-term consequences.

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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:02:47 JST Marc Veldhoen

     in reply to

     The vaccine caases a generally mild local inflammatory reaction. The antigen(s) present will be presented to your B and T cells, and those few recognising the antigen will be selected, they expand, mature in function, many will die, several will remain as memory cells.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:02:53 JST Marc Veldhoen

     in reply to

     Hence the long-term consequence of vaccination is the generation of antigen-specific memory B and T cells. These cells are very long lived, and will remain for many years to the rest of your life. They are the basis of your subsequent immune response against the same antigen
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:01 JST Marc Veldhoen

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     Ah, but what about those negative consequences, those often claimed we do not know about, we cannot know about till we wait 3, 5, 10, 50, 100 years... a seemingly powerful argument against the new COVID-19 vaccines. However, this is not as strong argument as you may think.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:07 JST Marc Veldhoen

     in reply to

     The only side effects are derived from that initial inflammatory reaction (RNA is short-lived). It is a short response. Some people are more sensitive to it, resulting in variable degrees of side effects: pain at the injection site, painful arm, swollen local lymph nodes,
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     AnthonyJK-Admin repeated this.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:12 JST Marc Veldhoen

     in reply to

     fever, feeling tired, nausea, etc. This includes other side effects from inflammatory responses such as myocarditis in more susceptible groups: males from the ages of puberty to about 40. ~4 days after vaccination.

     So far, no surprises at all.
     https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00059-5/fulltext
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     AnthonyJK-Admin repeated this.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:20 JST Marc Veldhoen

     in reply to

     There are no surpises. That inflammatory response is over within a few weeks. Side effects are mainly noted in the first 2-weeks, latest within 2 months. This is the reason, after lots of experience with vaccines, trials run for 2-3 months.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:29 JST Marc Veldhoen

     in reply to

     No, we cannot claim that side effects cannot, 100% sure, ever happen after 2 months. Science does not do 100%. But, the evidence that it is extremely unlikely to happen is very strong after a phase 3 trial.

     But, there is another aspect.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:36 JST Marc Veldhoen

     in reply to

     Some side effects are extremely rare. A phase 3 trial has 10.000s participants. That is not enough to catch rare events that happen 1 in 100.000 or 1 in 1M. That is why, all medication, is monitored in phase 4: when the vaccine is in use. And yes, that works, the 1/1M
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     AnthonyJK-Admin repeated this.
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     Marc Veldhoen (marc_veld@mastodon.online)'s status on Sunday, 18-Feb-2024 21:03:51 JST Marc Veldhoen

     in reply to

     bloodcloth effects with the vector (not mRNA) vaccines was discovered. Note these effects were there within 14-days after vaccination.

     So no, all those arguments about not knowing long-term effects are really not as strong as you may think, they indicate lack of knowledge.
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