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   Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:50 JST Jeff Gilchrist

   • Michael Lin, MD PhD

   Many people have anecdotally discovered and reported that Novavax doses had much lower side effects than when they received an mRNA shot. Multiple studies have now shown this to be the case as well. One preprint study (supported by Novavax) that compares the reactogenicity (frequency of side effects) of Novavax and mRNA vaccines ( https://medrxiv.org/content/10.1101/2023.05.31.23290594v1.full ). H/T: @michaelzlin 10/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:41 JST Jeff Gilchrist

     in reply to

     While vaccines are important, they should be the last layer of protection to rely on in case all the other layers fail and you end up getting exposed to a pathogen. Vaccines should not be the one and only layer governments all seem to be currently relying on. 18/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:42 JST Jeff Gilchrist

     in reply to

     FYI, I do not work for Novavax or have any investments or make any money from Novavax selling products. I am a little confused as to why Novavax just recently filed their regulatory approval paperwork with Health Canada as many people are waiting for the fall boosters so it would be a shame if they were not available soon like the mRNA fall boosters are expected to be. 17/

     Paul Cantrell repeated this.
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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:43 JST Jeff Gilchrist

     in reply to

     Now you have more details as to how Novavax is different and some of the nice benefits including for people who had mRNA shots previously. I'm hoping that the Matrix-M adjuvant will again show its ability to broaden the immune system's ability to choose epitopes so that it might continue to work better for upcoming variants as it did when BA.1 and BA.5 emerged. 16/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:44 JST Jeff Gilchrist

     in reply to

     Neutralising antibodies against Omicron BA.1 and BA.2 were higher with Novavax after mRNA compared to two mRNA doses. The mRNA + Novavax combination also had the lowest rate of breakthrough infections and the study also found fewer moderate and severe systemic adverse effects for Novavax than Pfizer mRNA. 15/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:46 JST Jeff Gilchrist

     in reply to

     • Michael Lin, MD PhD

     A randomized controlled trial found that getting a Novavax dose after Pfizer mRNA elicited the highest humoral and peak cellular immune responses ( https://www.journalofinfection.com/article/S0163-4453(23)00330-4/fulltext ). H/T: @michaelzlin 14/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:47 JST Jeff Gilchrist

     in reply to

     One study found that getting Novavax as a booster after mRNA "may enhance the persistence and durability of vaccine-mediated immunity compared to mRNA options" with slower decay rate compared to an mRNA booster dose and less side effects than mRNA boosters ( https://www.tandfonline.com/doi/full/10.1080/14760584.2023.2232020 ). H/T: @daniel_e_park 13/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:48 JST Jeff Gilchrist

     in reply to

     What about people who had mRNA doses previously but want to consider Novavax?

     There have been several studies now that found mixing the two, getting mRNA and then Novavax actually gave better results than just mRNA on its own. 12/

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     Jeff Gilchrist (jeffgilchrist@mstdn.science)'s status on Monday, 11-Sep-2023 02:21:49 JST Jeff Gilchrist

     in reply to

     They found a notable difference in the percentage of reported side effect symptoms with Novavax being lower in each category:
     * 30.8% lower muscle pain
     * 30.4% lower injection site pain
     * 25.7% lower fatigue
     * 25.4% lower injection site tenderness
     * 24.9% lower malaise
     * 22.4% lower swelling
     * 18.3% lower headache
     * 17.5% lower joint pain
     * 13% lower redness
     * 12% lower fever
     * 3.5% lower nausea/vomiting

     11/