"From Original Antigenic Sin (OAS) to the Universal Influenza Virus Vaccine" (Henry et al.); influenza vaccine has taught us a lot and the prospects are frightening if OAS plays out re COVID vaccine
Simple yet important types of considerations for the challenge is that the first prime or exposure or 'imprinting' will prejudice how one will respond post vaccine; a benign coronavirus can be deadly
Dr. Paul Alexander
5 hr ago
https://palexander.substack.com/p/from-original-antigenic-sin-oas-to