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A new study shows that an abnormally active immune system, a characteristic of long COVID patients, largely subsides two years after the initial infection. The finding offers hope that gradual recovery is possible in some long COVID patients. One in 10 COVID-19 patients, even those with a mild infection, suffer from a range of symptoms such as fatigue, brain fog, shortness of breath, heart palpitations, and depression. These lingering symptoms collectively called long COVID are now recognized as disability under the Americans with Disabilities Act and can continue for weeks, months, or even years. While scientists don’t know what causes long COVID, a hyperactive immune system appears to play a major role in persistent symptoms. A new study, published in Nature Communications, now shows that this heightened immune response calms down in long COVID patients 24 months after initial infection.