Tried playing BG3 on a different mac, with the same account. Worked fine. Same on a Steam Deck, just in case. Did the full hardware test, let the machine stay powered off for a few minutes to allow any ghosts in the capacitors to depart, notwithstanding.
Launched BG3 on the cursed machine. It worked! Hooray! Took a celebratory screenshot, switched spaces to look at it, switched spaces back, and as soon as the space-switch slide animation *began*… full-screen freeze, crash.
OS reinstall it is.