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@brion yeah, I was just using this route as the example in my human-computer interface class. I'm doing a project on selecting transportation modes based on real experience like door-to-door times.

The drive time from SF to Portland is about 15 hours, iirc. While it's possible to do that if you have multiple drivers and can trade off, it's more likely that you'll need to stop for meals and sleep, so I estimated a door-to-door time of 29 hours (15 drive, 8 sleep, 6 meals).